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| AVi | Date: Sunday, 12.10.2008, 16:06 | Message # 1 |
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Messages: 69
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| Программа для отправки почты с любого e-mail адреса(маски). Работает через белорусский почтовик, и сообщение может приходить не сразу. (!)Если появилась ошибка 537 "Your network does not have access to this account", это значит что аккаунт через который отправляется почта - заблочен, и я исправлю эту ошибку в течении дня, и выложу обновленную версию программы уже с новым аккаунтом здесь. Файлы контакт листа, и масок сохраняются на C:\, clist.txt и mlist.txt соответственно. Некоторые старые версии тут Mail sender Dark version
[СКАЧАТЬ 15.03.2009]
[СКАЧАТЬ rar 15.03.2009]
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Group: Гости
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| tcsindustryo | Date: Wednesday, 19.03.2014, 08:37 | Message # 20 |
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Group: Гости
| Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive pharmaceutical that is on the whole used after allogeneic organ move to subdue the activity of the passive's immune system and so debase the imperil of tool rejection. It is also second-hand in a current preparation in the treatment of atopic dermatitis (eczema), dictatorial refractory uveitis after bone marrow transplants, exacerbations of token variation disease, and the fleece condition vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sampling that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) putting out by T-cells.
Dead letter
Tacrolimus was discovered in 1984; it was all of a add up to the prime macrolide immunosuppressants discovered, preceded by the invention of rapamycin (sirolimus) on Rapa Nui (Easter Islet) in 1975.[1] It is produced on a archetype of loam bacterium,Streptomyces tsukubaensis.[2] The high regard tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3]
Tacrolimus was to begin approved via the Comestibles and Drug Supplying (FDA) in 1994 for make use of in liver transplantation; this has been extended to number kidney, affection, miniature bowel, pancreas, lung, trachea, husk, cornea, bone marrow, and limb transplants.
Availability
The branded version of the medicate is owned by Astellas Pharma, and is sold below the vocation names Prograf assumed twice everyday,Advagraf, a sustained release formulation allowing in the good old days day after day dosing, and Protopic (Eczemus in Pakistan by Brookes Pharma), the current formulation.[4] Advagraf is at one's fingertips in 0.5, 1, 3 and 5 mg capsules, the not great is concentrations of 0.1% and 0.03%.
A other once-daily formulation of tacrolimus is in Development 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic list that reduces the peak-to-trough assortment in blood levels compared to twice-daily tacrolimus.[5] Materials from the premier Viewpoint 3 woe in steady kidney move patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.[6] A other Juncture 3 litigation in de novo patients is ongoing.[7]
Logical positivism of strength
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to turn on calcineurin. Calcineurin then dephosphorylates the transcription constituent NF-AT (atomic aspect of activated T-cells), which moves to the pith of the T-cell and increases the labour of genes coding to save IL-2 and common cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8] In charge, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin wise inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9] Although this liveliness is alike resemble to ciclosporin, studies secure shown that the occurrence of keen also brush is reduced by tacrolimus use from ciclosporin.[10] Although short-term immunosuppression concerning patient and extortion survival is found to be be like between the two drugs, tacrolimus results in a more favorable lipid profile, and this may acquire substantial long-term implications given the prognostic play of renunciation on implant survival.[11]
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| fmyykjo | Date: Friday, 21.03.2014, 06:45 | Message # 21 |
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Group: Гости
| Tacrolimus (also FK-506 or fujimycin, truck names Prograf, Advagraf, Protopic) is an immunosuppressive pharmaceutical that is on the whole acclimatized after allogeneic medium transfer to trim down the activity of the patient's untouched system and so debase the imperil of medium rejection. It is also utilized in a up to date preparation in the treatment of atopic dermatitis (eczema), harsh refractory uveitis after bone marrow transplants, exacerbations of minimal transform infirmity, and the crust train vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation decoction of a Japanese sully test that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) putting out past T-cells.
Dead letter
Tacrolimus was discovered in 1984; it was among the maiden macrolide immunosuppressants discovered, preceded past the development of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.[1] It is produced by way of a type of soil bacterium,Streptomyces tsukubaensis.[2] The handle tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3]
Tacrolimus was first approved by means of the Edibles and Narcotize Management (FDA) in 1994 someone is concerned make use of in liver transplantation; this has been extended to embrace kidney, heart, miniature bowel, pancreas, lung, trachea, overlay, cornea, bone marrow, and limb transplants.
Availability
The branded type of the drug is owned next to Astellas Pharma, and is sold secondary to the career names Prograf given twice daily,Advagraf, a sustained unfetter formulation allowing once day after day dosing, and Protopic (Eczemus in Pakistan before Brookes Pharma), the timely formulation.[4] Advagraf is at one's fingertips in 0.5, 1, 3 and 5 mg capsules, the correct is concentrations of 0.1% and 0.03%.
A other once-daily formulation of tacrolimus is in Aspect 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough rank in blood levels compared to twice-daily tacrolimus.[5] Statistics from the premier Viewpoint 3 litigation in deep-rooted kidney shift patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.[6] A other Juncture 3 effort in de novo patients is ongoing.[7]
Instrument of action
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription go-between NF-AT (nuclear factor of activated T-cells), which moves to the core of the T-cell and increases the undertaking of genes coding in behalf of IL-2 and tied up cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8] In group specifically, Tacrolimus reduces peptidyl-prolyl isomerase operation at hand binding to the immunophilin FKBP12 (FK506 binding protein) creating a fresh complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin and so inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9] Although this liveliness is similar to ciclosporin, studies have shown that the occurrence of keen also brush is reduced nearby tacrolimus capitalize on over ciclosporin.[10] Although short-term immunosuppression as regards unyielding and graft survival is develop to be comparable between the two drugs, tacrolimus results in a more favorable lipid portrait, and this may have urgent long-term implications given the prognostic act upon of denial on corruption survival.[11]
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